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Article

Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences.

PloS one - 1 Jan 2014

Eriksson Emily M, Liegler Teri, Keh Chris E, Karlsson Annika C, Holditch Sara J, Pilcher Christopher D, Loeb Lisa, Nixon Douglas F, Hecht Frederick M

Abstract excerpt

CD8+ T cells are important for HIV-1 virus control, but are also a major contributing factor that drives HIV-1 virus sequence evolution. Although HIV-1 cytotoxic T cell (CTL) escape mutations are a common aspect during HIV-1 infection, less is known about the importance of T cell pressure in reversing HIV-1 virus back to a consensus sequences. In this study we aimed to assess the frequency with which reversion of...

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Share to CD8-Positive T-Lymphocytes
Share to Consensus Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HIV Infections

Share to Sequence Analysis, RNA

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 25919393
DOI: 10.1371/journal.pone.0120787
PMCID: PMC4412704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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