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Article

Viral persistence <i>in vivo</i> through selection of neutralizing antibody-escape variants

25 Feb 2000

Abstract excerpt

Despite initial virus control by CD8(+) cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections. The role of neutralizing antibodies (nAbs) in controlling disease progression is unclear. Therefore, the phenomenon of viral evasion from the nAb response and its implications for virus persistence remain...

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PMID: 10688894
DOI: 10.1073/pnas.040558797

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