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Article

A CD8 T-cell epitope variant enhances immune targeting to a recombinant picornavirus vaccine antigen.

Viral immunology - 1 Sept 2014

Bell Michael P, Renner Danielle N, Johnson Aaron J, Pavelko Kevin D

Abstract excerpt

Recombinant virus vaccines are often less effective due to immunodominant responses against endogenous vector antigens. However, the use of small RNA virus vectors provides an opportunity to limit host exposure to endogenous virus antigens and focus immune responses on the desired vaccine antigen. Using the Daniel's strain of Theiler's murine encephalomyelitis virus, we have identified strategies to modulate...

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Share to Antigens, Viral
Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Picornaviridae Infections

Share to Receptor, ErbB-2

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Source

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Identifiers

PMID: 25025983
DOI: 10.1089/vim.2014.0045
PMCID: PMC4150375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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