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Article

Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides.

Nature communications - 1 Jan 2013

Valkenburg Sophie A, Quiñones-Parra Sergio, Gras Stephanie, Komadina Naomi, McVernon Jodie, Wang Zhongfang, Halim Hanim, Iannello Pina, Cole Catherine, Laurie Karen, Kelso Anne, Rossjohn Jamie, Doherty Peter C, Turner Stephen J, Kedzierska Katherine

Abstract excerpt

Influenza A virus-specific CD8(+) cytotoxic T lymphocytes (CTLs) provide a degree of cross-strain protection that is potentially subverted by mutation. Here we describe the sequential emergence of such variants within CTL epitopes for a persistently infected, immunocompromised infant. Further analysis in immunodeficient and wild-type mice supports the view that CTL escape variants arise frequently in influenza,...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Influenza A Virus, H3N2 Subtype

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Source

Identifiers

PMID: 24173108
DOI: 10.1038/ncomms3663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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