Article
Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans.
The Journal of experimental medicine - 3 Jul 2017
Murray Susan E, Nesterenko Pavlo A, Vanarsdall Adam L, Munks Michael W, Smart Savannah M, Veziroglu Eren M, Sagario Lavinia C, Lee Ronzo, Claas Frans H J, Doxiadis Ilias I N, McVoy Michael A, Adler Stuart P, Hill Ann B
Abstract excerpt
Cytomegalovirus (CMV)-based vaccines have shown remarkable efficacy in the rhesus macaque model of acquired immune deficiency syndrome, enabling 50% of vaccinated monkeys to clear a subsequent virulent simian immunodeficiency virus challenge. The protective vaccine elicited unconventional CD8 T cell responses that were entirely restricted by MHC II or the nonclassical MHC I molecule, MHC-E. These unconventional...
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