Article
Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells.
Nature - 2 Jun 1994
Bertoletti A, Sette A, Chisari F V, Penna A, Levrero M, De Carli M, Fiaccadori F, Ferrari C
Abstract excerpt
It has been suggested that mutations within immunodominant cytotoxic T-lymphocyte (CTL) epitopes may be exploited by viruses to evade protective immune responses critical for clearance. Viral escape could originate from passive mechanisms, such as mutations within crucial CTL epitopes, either aff...
Topics
- Amino Acid Sequence
- Cell Line
- Chronic Disease
- HLA-A2 Antigen
- Hepatitis B
- Hepatitis B Core Antigens
- Hepatitis B virus
- Humans
- Immunodominant Epitopes
- Interferon-gamma
- Molecular Sequence Data
- Mutation
- Nucleoproteins
- Receptors, Antigen, T-Cell
- T-Lymphocytes, Cytotoxic