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Article

The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent (p)ppGpp-synthesizing and -degrading activities.

Journal of bacteriology - 1 Aug 1998

Martínez-Costa O H, Fernández-Moreno M A, Malpartida F

Abstract excerpt

Streptomyces coelicolor (p)ppGpp synthetase (Rel protein) belongs to the RelA and SpoT (RelA/SpoT) family, which is involved in (p)ppGpp metabolism and the stringent response. The potential functions of the rel gene have been examined. S. coelicolor Rel has been shown to be ribosome associated, and its activity in vitro is ribosome dependent. Analysis in vivo of the active recombinant protein in well-defined...

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Identifiers

PMID: 9696759
DOI: 10.1128/JB.180.16.4123-4132.1998
PMCID: PMC107407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent (p)ppGpp-synthesizing and -degrading activities.PMID 9696759Read ↗

Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus.Semantic proximity Read ↗

Molecular and functional analysis of the ribosomal L11 and S12 protein genes (rplK and rpsL) of Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation.Semantic proximity Read ↗

Overexpression of the relA gene in Escherichia coli.Semantic proximity Read ↗

Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-Site.Semantic proximity Read ↗

Activation of RelA by pppGpp as the basis for its differential toxicity over ppGpp in Escherichia coli.Semantic proximity Read ↗

The roles of RelA/(p)ppGpp in glucose-starvation induced adaptive response in the zoonotic Streptococcus suis.Semantic proximity Read ↗

Roles of <i>rel</i><sub><i>Spn</i></sub> in stringent response, global regulation and virulence of serotype 2 <i>Streptococcus pneumoniae</i> D39Semantic proximity Read ↗

The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Three gene products govern (p)ppGpp production by <i>Streptococcus mutans</i>Semantic proximity Read ↗

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.Semantic proximity Read ↗

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