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Article

Activation of RelA by pppGpp as the basis for its differential toxicity over ppGpp in Escherichia coli.

Journal of biosciences - 1 Jan 2020

Sanyal Rajeshree, Harinarayanan Rajendran

Abstract excerpt

The nucleotide derivatives (p)ppGpp, comprising ppGpp and pppGpp, are important signalling molecules that control various facets of gene regulation and protein synthesis in Escherichia coli. Their synthesis is catalysed by RelA (in response to amino acid limitation) and by SpoT (in response to the limitation of carbon source or fatty acids). SpoT is also a hydrolase for degradation of both ppGpp and pppGpp, while...

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PMID: 32020910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Activation of RelA by pppGpp as the basis for its differential toxicity over ppGpp in Escherichia coli.PMID 32020910Read ↗

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