Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of the relA gene in Escherichia coli.

The Journal of biological chemistry - 25 Feb 1991

Schreiber G, Metzger S, Aizenman E, Roza S, Cashel M, Glaser G

Abstract excerpt

Intracellular levels of guanosine 3',5'-bispyrophosphate (ppGpp) governed by the relA gene are normally regulated by aminoacyl-tRNA availability for protein synthesis. An experimental system is described in which cellular levels of ppGpp are controlled instead by induction of plasmid pKK223-3 derivatives with the relA structural gene, or portions thereof, under control of the Ptac promoter. In amino acid-rich...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Escherichia coli
Share to Genes, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Promoter Regions, Genetic

Share to Transcription, Genetic

Source

Identifiers

PMID: 1899866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of the relA gene in Escherichia coli.PMID 1899866Read ↗

Characterization of RelA in Acinetobacter baumannii.Semantic proximity Read ↗

The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent (p)ppGpp-synthesizing and -degrading activities.Semantic proximity Read ↗

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.Semantic proximity Read ↗

Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-Site.Semantic proximity Read ↗

Systematic production of inactivating and non-inactivating suppressor mutations at the relA locus that compensate the detrimental effects of complete spot loss and affect glycogen content in Escherichia coli.Semantic proximity Read ↗

Mutation in the relA gene of Vibrio cholerae affects in vitro and in vivo expression of virulence factors.Semantic proximity Read ↗

Proteome phenotyping of ΔrelA mutants in Enterococcus faecalis V583.Semantic proximity Read ↗

The (p)ppGpp synthetase RelA contributes to stress adaptation and virulence in Enterococcus faecalis V583Semantic proximity Read ↗

Delayed-relaxed response explained by hyperactivation of RelE.Semantic proximity Read ↗

Temperature-sensitive growth and decreased thermotolerance associated with relA mutations in Escherichia coli.Semantic proximity Read ↗

Toxic effects of high levels of ppGpp in Escherichia coli are relieved by rpoB mutations.Semantic proximity Read ↗

Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.