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Article

Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2).

Journal of bacteriology - 1 Jun 2001

Sun J, Hesketh A, Bibb M

Abstract excerpt

Deletion of the (p)ppGpp synthetase gene, relA, of Streptomyces coelicolor A3(2) results in loss of production of the antibiotics actinorhodin (Act) and undecylprodigiosin (Red) and delayed morphological differentiation when the mutant is grown under conditions of nitrogen limitation. To analyze the role of (p)ppGpp as an intracellular signaling molecule for the initiation of antibiotic production, several...

Topics

Adenosine
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Guanosine Pentaphosphate
Ligases
Molecular Sequence Data
Mutation
Phosphates
Pyrophosphatases
Sequence Homology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptomyces

Thiostrepton

Trans-Activators

Source

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Identifiers

PMID: 11344157
DOI: 10.1128/JB.183.11.3488-3498.2001
PMCID: PMC99647

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Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2).PMID 11344157Read ↗

The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent (p)ppGpp-synthesizing and -degrading activities.Semantic proximity Read ↗

A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Genetic mapping and characterization of novel mutations which suppress the effect of a relC mutation on antibiotic production in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Molecular and functional analysis of the ribosomal L11 and S12 protein genes (rplK and rpsL) of Streptomyces coelicolor A3(2).Semantic proximity Read ↗

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The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

A relA(S) suppressor mutant allele of Bacillus subtilis which maps to relA and responds only to carbon limitation.Semantic proximity Read ↗

A relaxed (rel) mutant of Streptomyces coelicolor A3(2) with a missing ribosomal protein lacks the ability to accumulate ppGpp, A-factor and prodigiosin.Semantic proximity Read ↗

A single amino acid substitution in region 1.2 of the principal sigma factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production.Semantic proximity Read ↗

Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus.Semantic proximity Read ↗

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