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Article

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.

Nucleic acids research - 28 Feb 2018

Kudrin Pavel, Dzhygyr Ievgen, Ishiguro Kensuke, Beljantseva Jelena, Maksimova Elena, Oliveira Sofia Raquel Alves, Varik Vallo, Payoe Roshani, Konevega Andrey L, Tenson Tanel, Suzuki Tsutomu, Hauryliuk Vasili

Abstract excerpt

During amino acid starvation the Escherichia coli stringent response factor RelA recognizes deacylated tRNA in the ribosomal A-site. This interaction activates RelA-mediated synthesis of alarmone nucleotides pppGpp and ppGpp, collectively referred to as (p)ppGpp. These two alarmones are synthesized by addition of a pyrophosphate moiety to the 3' position of the abundant cellular nucleotide GTP and less abundant...

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Identifiers

PMID: 29390134
DOI: 10.1093/nar/gky023
PMCID: PMC5829649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.PMID 29390134Read ↗

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