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Article

PTEN Is a Potent Suppressor of Small Cell Lung Cancer

31 Jan 2014

Abstract excerpt

UNLABELLED: Small cell lung carcinoma (SCLC) is a highly metastatic tumor type with neuroendocrine features and a dismal prognosis. PTEN mutations and PIK3CA activating mutations have been reported in SCLC but the functional relevance of this pathway is unknown. The PTEN/PIK3CA pathway was interrogated using an AdenoCre-driven mouse model of SCLC harboring inactivated Rb and p53. Inactivation of one allele of...

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PMID: 24482365
DOI: 10.1158/1541-7786.mcr-13-0554

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