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Article

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2014

Umemura Shigeki, Mimaki Sachiyo, Makinoshima Hideki, Tada Satoshi, Ishii Genichiro, Ohmatsu Hironobu, Niho Seiji, Yoh Kiyotaka, Matsumoto Shingo, Takahashi Akiko, Morise Masahiro, Nakamura Yuka, Ochiai Atsushi, Nagai Kanji, Iwakawa Reika, Kohno Takashi, Yokota Jun, Ohe Yuichiro, Esumi Hiroyasu, Tsuchihara Katsuya, Goto Koichi

Abstract excerpt

INTRODUCTION: The information regarding therapeutically relevant genomic alterations in small cell lung cancer (SCLC) is not well developed. We analyzed the SCLC genome using an integrative approach to stratify the targetable alterations. METHODS: We performed whole exon sequencing (n = 51) and copy number analysis (n =47) on surgically resected tumors and matched normal tissue samples from treatment-naive...

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Identifiers

PMID: 25122428
DOI: 10.1097/JTO.0000000000000250
PMCID: PMC4154841

Genes

AKT2
AKT3
MYC
PTEN
RICTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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