The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway.

doi:10.1101/gad.12.15.2371

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Article

The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway.

Genes & development - 1 Aug 1998

Su Y C, Treisman J E, Skolnik E Y

Abstract excerpt

Dorsal closure in the Drosophila embryo occurs during the later stages of embryogenesis and involves changes in cell shape leading to the juxtaposition and subsequent adherence of the lateral epidermal primordia over the amnioserosa. Dorsal closure requires the activation of a conserved c-jun ami...

Topics

Amino Acid Sequence
Animals
Body Patterning
Caenorhabditis elegans
Calcium-Calmodulin-Dependent Protein Kinases
Conserved Sequence
Drosophila
Drosophila Proteins
Enzyme Activation
Evolution, Molecular
Gene Expression Regulation, Developmental
Genes, Insect
In Situ Hybridization

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Intracellular Signaling Peptides and Proteins

JNK Mitogen-Activated Protein Kinases

MAP Kinase Kinase Kinases

Mitogen-Activated Protein Kinases

Molecular Sequence Data

Source

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Identifiers

PMID: 9694801
DOI: 10.1101/gad.12.15.2371
PMCID: PMC317054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9694801-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.