Article
Tissue inhibitor of metalloproteinase (TIMP)-1 induces differentiation and an antiapoptotic phenotype in germinal center B cells.
Blood - 15 Aug 1998
Guedez L, Courtemanch L, Stetler-Stevenson M
Abstract excerpt
Tissue inhibitors of metalloproteinases (TIMPs) have been shown to be multifunctional factors. Contrasting with their enzyme-inhibitory activity, TIMPs also promote cell growth. Previously, we have reported an enhanced expression of TIMP-1 by normal reactive B cells and high-grade lymphomas. In t...
Topics
- Apoptosis
- B-Lymphocyte Subsets
- Burkitt Lymphoma
- Cell Differentiation
- Embryonal Carcinoma Stem Cells
- Germinal Center
- Herpesviridae Infections
- Herpesvirus 4, Human
- Humans
- Immunoglobulin M
- Neoplasm Proteins
- Neoplastic Stem Cells
- Neprilysin
- Phenotype
- Receptors, IgE
- Recombinant Fusion Proteins
- Tissue Inhibitor of Metalloproteinase-1
- Transfection