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Article

Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression.

International journal of molecular sciences - 22 Jan 2023

Ishihara Rei, Oda Tsukasa, Murakami Yuki, Matsumura Ikuko, Watanabe Saki, Asao Yuta, Masuda Yuta, Gotoh Nanami, Kasamatsu Tetsuhiro, Takei Hisashi, Kobayashi Nobuhiko, Sasaki Nobuo, Saitoh Takayuki, Murakami Hirokazu, Handa Hiroshi

Abstract excerpt

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous matrix metalloproteinase inhibitors. TIMP1 is produced by cancer cells and has pleiotropic activities. However, its role and source in multiple myeloma (MM) are unclear. Here, we evaluated TIMP1 protein and mRNA levels in bone marrow (BM) plasma cells and assessed the effects of TIMP1 expression on fibroblast invasive capacity using three-dimensional...

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Identifiers

PMID: 36768545
DOI: 10.3390/ijms24032216
PMCID: PMC9917104

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