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Article

TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.

PloS one - 1 Jan 2012

Jung Young Suk, Liu Xu-Wen, Chirco Rosemarie, Warner Richard B, Fridman Rafael, Kim Hyeong-Reh Choi

Abstract excerpt

Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) regulate epithelial-mesenchymal transition (EMT) critical for the development of epithelial organs as well as cancer cell invasion. TIMP-1 is frequently overexpressed in several types of human cancers and serves as a prognostic marker. The present study investigates the roles of TIMP-1 on the EMT process and formation of the lumen-like...

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Source

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Identifiers

PMID: 22701711
DOI: 10.1371/journal.pone.0038773
PMCID: PMC3372473

Genes

ZEB1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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