Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis.

British journal of cancer - 23 Oct 2006

Davidsen M L, Würtz S Ø, Rømer M U, Sørensen N M, Johansen S K, Christensen I J, Larsen J K, Offenberg H, Brünner N, Lademann U

Abstract excerpt

Tissue inhibitor of metalloproteinases-1 (TIMP-1) is one of four inhibitors of the matrix metalloproteinases, which are capable of degrading most components of the extracellular matrix. However, in recent years, TIMP-1 has been recognised as a multifunctional protein, playing a complex role in ca...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Cell Transformation, Neoplastic
Share to Cytarabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Etoposide

Share to Mice, Inbred BALB C

Share to Tissue Inhibitor of Metalloproteinase-1

Share to Vincristine

Source

Open in PubMed Open full text

Identifiers

PMID: 17047657
DOI: 10.1038/sj.bjc.6603378
PMCID: PMC2360707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17047657-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis.PMID 17047657Read ↗

Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host.Semantic proximity Read ↗

Phenotypic alterations in Caki-1 cells as a consequence of TIMP-1 overexpression.Semantic proximity Read ↗

Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancerSemantic proximity Read ↗

Cancer Gene Therapy with Tissue Inhibitors of Metalloproteinases (TIMPs)Semantic proximity Read ↗

TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.Semantic proximity Read ↗

Whole Organism Profiling of the Timp Gene FamilySemantic proximity Read ↗

TIMP‐1 expression in human colorectal cancer is associated with TGF‐B1, LOXL2, INHBA1, TNF‐AIP6 and TIMP‐2 transcript profilesSemantic proximity Read ↗

Tissue inhibitor of matrix metalloproteinase-1 suppresses apoptosis of mouse bone marrow stromal cell line MBA-1.Semantic proximity Read ↗

TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: a potential novel approach to the treatment of metastatic colorectal cancer.Semantic proximity Read ↗

TIMP-1 Increases Expression and Phosphorylation of Proteins Associated with Drug Resistance in Breast Cancer CellsSemantic proximity Read ↗

siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.Semantic proximity Read ↗

The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.