Article
TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis.
British journal of cancer - 23 Oct 2006
Davidsen M L, Würtz S Ø, Rømer M U, Sørensen N M, Johansen S K, Christensen I J, Larsen J K, Offenberg H, Brünner N, Lademann U
Abstract excerpt
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is one of four inhibitors of the matrix metalloproteinases, which are capable of degrading most components of the extracellular matrix. However, in recent years, TIMP-1 has been recognised as a multifunctional protein, playing a complex role in cancer. In this regard, several studies have demonstrated an antiapoptotic effect of TIMP-1 in a number of different cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.