Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer

15 Apr 2022

Abstract excerpt

Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were originally identified as endogenous inhibitors of matrixin and adamalysin endopeptidase activity. The matrixins and adamalysins are the major mediators of extracellular matrix (ECM) turnover, thus making TIMPs important regulators of ECM structure and composition. Despite their high sequence identity and relative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Galectins and Cancer Biology
Share to Peptidase Inhibition and Analysis
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35436325
DOI: 10.1093/carcin/bgac037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancerPMID 35436325Read ↗

A Comprehensive Bioinformatics Analysis of TIMP2 in Multiple MalignanciesSemantic proximity Read ↗

The TIMP protein family: diverse roles in pathophysiologySemantic proximity Read ↗

Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironmentSemantic proximity Read ↗

Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic AnalysisSemantic proximity Read ↗

The Role of Tissue Inhibitors of Metalloproteinases in Tumorigenesis and MetastasisSemantic proximity Read ↗

Whole Organism Profiling of the Timp Gene FamilySemantic proximity Read ↗

An integrative analysis reveals the prognostic and immunological role of TIMP gene family in pan-cancerSemantic proximity Read ↗

Multi-omics Analysis and Functional Characterization of the TIMP1 in Colorectal CancerSemantic proximity Read ↗

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.Semantic proximity Read ↗

Tissue Inhibitor of Metalloproteinases-4. The road less traveledSemantic proximity Read ↗

Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular PathologySemantic proximity Read ↗

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.