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Article

Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer

30 Apr 2016

Abstract excerpt

BACKGROUND: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a multifunctional protein that can directly regulate apoptosis and metastasis. In this study, we investigated the functional and molecular mechanisms by which TIMP-1 influences triple-negative breast cancer (TNBC). METHODS: The expression level of TIMP-1 in breast cancer tissues was analyzed using the ONCOMINE microarray database. The overall...

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PMID: 27130446
DOI: 10.1186/s12943-016-0515-5

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