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The TIMP protein family: diverse roles in pathophysiology

29 Jan 2024

Abstract excerpt

The tissue inhibitors of matrix metalloproteinases (TIMPs) are a family of four matrisome proteins classically defined by their roles as the primary endogenous inhibitors of metalloproteinases (MPs). Their functions however are not limited to MP inhibition, with each family member harboring numerous MP-independent biological functions that play key roles in processes such as inflammation and apoptosis. Because of...

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PMID: 38284123
DOI: 10.1152/ajpcell.00699.2023

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