Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of p53 and p21WAF1/CIP1 proteins in gastric and esophageal cancers: comparison with mutations of the p53 gene.

Digestive diseases and sciences - 1 Feb 1998

Seta T, Imazeki F, Yokosuka O, Saisho H, Suzuki T, Koide Y, Isono K

Abstract excerpt

The p53 gene has been shown to be commonly mutated in various human cancers, and mutant p53 can act as a dominant oncogene. The intact p53 protein is also known to induce the cyclin-dependent kinase inhibitor p21WAF1/CIP1 and is implicated in cell cycle arrest. We investigated p53 gene alterations in gastric adenocarcinoma and esophageal squamous cell carcinoma to elucidate the association of the nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Aged
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Genes, p53

Share to Mutation

Share to Sequence Analysis, DNA

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 9512119
DOI: 10.1023/a:1018889818855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of p53 and p21WAF1/CIP1 proteins in gastric and esophageal cancers: comparison with mutations of the p53 gene.PMID 9512119Read ↗

Expression of p21WAF1/CIP1 is unrelated to p53 tumour suppressor gene status in oral squamous cell carcinomas.Semantic proximity Read ↗

Expression of the cyclin dependent kinase inhibitor p21WAF1/CIP1 in oesophageal squamous cell carcinomas.Semantic proximity Read ↗

p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations.Semantic proximity Read ↗

P21WAF1/Cip1 gene expression in primary human hepatocellular carcinoma and its relationship with P53 gene mutation.Semantic proximity Read ↗

Deregulated p21(WAF1) overexpression impacts survival of surgically resected esophageal squamous cell carcinoma patients.Semantic proximity Read ↗

Expression of the p53 induced tumor suppressor p21waf1/cip1 in ovarian carcinomas: correlation with p53 and Ki-67 immunohistochemistry.Semantic proximity Read ↗

Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma.Semantic proximity Read ↗

p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.Semantic proximity Read ↗

Altered topographic expression of p21WAF1/CIP1/SDI1, bcl2 and p53 during gastric carcinogenesis.Semantic proximity Read ↗

p21WAF1 mutations and human malignancies.Semantic proximity Read ↗

Overexpression of the p53 tumor suppressor gene product in esophageal and gastric carcinomas.Semantic proximity Read ↗

p21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.