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Article

Expression of p53 and p21WAF1/CIP1 proteins in gastric and esophageal cancers: comparison with mutations of the p53 gene.

Digestive diseases and sciences - 1 Feb 1998

Seta T, Imazeki F, Yokosuka O, Saisho H, Suzuki T, Koide Y, Isono K

Abstract excerpt

The p53 gene has been shown to be commonly mutated in various human cancers, and mutant p53 can act as a dominant oncogene. The intact p53 protein is also known to induce the cyclin-dependent kinase inhibitor p21WAF1/CIP1 and is implicated in cell cycle arrest. We investigated p53 gene alteration...

Topics

Adenocarcinoma
Aged
Carcinoma, Squamous Cell
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA, Neoplasm
Esophageal Neoplasms
Female
Genes, p53
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Sequence Analysis, DNA

Stomach Neoplasms

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 9512119
DOI: 10.1023/a:1018889818855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9512119-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Expression of p53 and p21WAF1/CIP1 proteins in gastric and esophageal cancers: comparison with mutations of the p53 gene.PMID 9512119Read ↗

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