Article
Expression of the cyclin dependent kinase inhibitor p21WAF1/CIP1 in oesophageal squamous cell carcinomas.
Virchows Archiv : an international journal of pathology - 1 May 1997
Ohashi K, Nemoto T, Eishi Y, Matsuno A, Nakamura K, Hirokawa K
Abstract excerpt
To elucidate the role of CDK inhibitor p21WAF1/CIP1 in human oesophageal squamous cell carcinomas, we examined its expression immunohistochemically using surgically resected tissues from 25 patients, and have analyzed the relationship with alteration of p53 gene (F-SSCP analysis), proliferative activity (Ki-67 labelling index), frequency of apoptosis (in situ DNA nick end labelling), and degree of...
Topics
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- Base Sequence
- Carcinoma, Squamous Cell
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- DNA, Neoplasm
- Enzyme Inhibitors
- Esophageal Neoplasms
- Female
- Gene Expression Regulation, Neoplastic