Article
Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma.
Acta oto-laryngologica - 1 Jul 2005
Bandoh Nobuyuki, Hayashi Tatsuya, Takahara Miki, Kishibe Kan, Ogino Takeshi, Katayama Akihiro, Imada Masanobu, Nonaka Satoshi, Harabuchi Yasuaki
Abstract excerpt
CONCLUSIONS: Loss of p21 expression dependent on the p53 mutation may be associated with higher tumor cell proliferation, and low p27 expression may be associated with decreased spontaneous apoptosis, resulting in poorer prognosis in patients with maxillary sinus squamous cell carcinoma (SCC). OBJECTIVE: We have previously reported that p53 mutations and decreased spontaneous apoptosis were associated with poor...
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