p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx.

doi:10.1002/(SICI)1096-9896(199710)183:2<156::AID-PATH908>3.0.CO;2-O

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Article

p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx.

The Journal of pathology - 1 Oct 1997

Nadal A, Jares P, Cazorla M, Fernández P L, Sanjuan X, Hernandez L, Pinyol M, Aldea M, Mallofré C, Muntané J, Traserra J, Campo E, Cardesa A

Abstract excerpt

p21WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21WAF1/Cip1 expression has been studied at both mRNA and protein levels in...

Topics

Adult
Aged
Aged, 80 and over
Blotting, Northern
Carcinoma, Squamous Cell
Cell Differentiation
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Gene Expression
Genes, p53
Humans
Immunoenzyme Techniques
Laryngeal Neoplasms
Male

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Neoplasm Proteins

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9390027
DOI: 10.1002/(SICI)1096-9896(199710)183:2<156::AID-PATH908>3.0.CO;2-O

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9390027-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.