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Article

Primary and secondary glioblastomas: from concept to clinical diagnosis.

Neuro-oncology - 1 Jan 1999

Kleihues P, Ohgaki H

Abstract excerpt

Glioblastomas may develop de novo (primary glioblastomas) or through progression from low-grade or anaplastic astrocytomas, (secondary glioblastomas). These subtypes of glioblastoma constitute distinct disease entities that evolve through different genetic pathways, affect patients at different ages, and are likely to differ in prognosis and response to therapy. Primary glioblastomas develop in older patients and...

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Source

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Identifiers

PMID: 11550301
DOI: 10.1093/neuonc/1.1.44
PMCID: PMC1919466

Genes

EGFR
MDM2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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