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Article

Primary and secondary glioblastomas: from concept to clinical diagnosis.

Neuro-oncology - 1 Jan 1999

Kleihues P, Ohgaki H

Abstract excerpt

Glioblastomas may develop de novo (primary glioblastomas) or through progression from low-grade or anaplastic astrocytomas, (secondary glioblastomas). These subtypes of glioblastoma constitute distinct disease entities that evolve through different genetic pathways, affect patients at different a...

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Source

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Identifiers

PMID: 11550301
DOI: 10.1093/neuonc/1.1.44
PMCID: PMC1919466

Genes

EGFR
MDM2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11550301-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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