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Article

Genetic pathways to primary and secondary glioblastoma.

The American journal of pathology - 1 May 2007

Ohgaki Hiroko, Kleihues Paul

Abstract excerpt

Glioblastoma is the most frequent and most malignant human brain tumor. The prognosis remains very poor, with most patients dying within 1 year after diagnosis. Primary and secondary glioblastoma constitute distinct disease subtypes, affecting patients of different age and developing through different genetic pathways. The majority of cases (>90%) are primary glioblastomas that develop rapidly de novo, without...

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Source

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Identifiers

PMID: 17456751
DOI: 10.2353/ajpath.2007.070011
PMCID: PMC1854940

Genes

EGFR
PTEN

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