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Article

Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

15 May 2007

Abstract excerpt

Glioblastoma multiforme (GBM) can present as either de novo or secondary tumors arising from previously diagnosed low-grade gliomas. Although these tumor types are phenotypically indistinguishable, de novo and secondary GBMs are associated with distinct genetic characteristics. PTEN mutations, which result in activation of the phosphoinositide 3-kinase (PI3K) signal transduction pathway, are frequent in de novo...

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PMID: 17504928
DOI: 10.1215/15228517-2007-003

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