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Article

Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein.

Oncogene - 23 Jul 1998

Huang P

Abstract excerpt

The tumor suppressor p53 plays a critical role in the regulation of the cell cycle and the maintenance of genetic stability. The 3'-->5' exonuclease activity of p53 has recently been recognized as a novel biochemical function of this molecule, but the biological significance of this activity remains elusive. Using an in vitro DNA replication assay with purified human DNA polymerases, p53 protein, and defined DNA...

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Identifiers

PMID: 9690508
DOI: 10.1038/sj.onc.1201946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein.PMID 9690508Read ↗

Suppression of mismatched mutation by p53: a mechanism for guarding genomic integrity.Semantic proximity Read ↗

p53 Protein exhibits 3'-to-5' exonuclease activity.Semantic proximity Read ↗

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A nuclear 3'-5' exonuclease proofreads for the exonuclease-deficient DNA polymerase alpha.Semantic proximity Read ↗

DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers.Semantic proximity Read ↗

Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H.Semantic proximity Read ↗

Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells.Semantic proximity Read ↗

Proofreading exonuclease activity of human DNA polymerase delta and its effects on lesion-bypass DNA synthesis.Semantic proximity Read ↗

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.Semantic proximity Read ↗

[P53 delta 37 protein exhibits 3'-5' exonuclease activity].Semantic proximity Read ↗

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