Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein.

doi:10.1038/sj.onc.1201946

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Article

Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein.

Oncogene - 23 Jul 1998

Huang P

Abstract excerpt

The tumor suppressor p53 plays a critical role in the regulation of the cell cycle and the maintenance of genetic stability. The 3'-->5' exonuclease activity of p53 has recently been recognized as a novel biochemical function of this molecule, but the biological significance of this activity rema...

Topics

Cell Nucleus
DNA Damage
DNA Helicases
DNA Polymerase I
DNA Primers
DNA Replication
Exodeoxyribonuclease V
Exodeoxyribonucleases
Humans
Leukemia
Mutation
Templates, Genetic
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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