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Article

p53 Protein exhibits 3'-to-5' exonuclease activity.

Cell - 28 Jun 1996

Mummenbrauer T, Janus F, Müller B, Wiesmüller L, Deppert W, Grosse F

Abstract excerpt

Highly purified p53 protein from different sources was able to degrade DNA with a 3'-to-5' polarity, yielding deoxynucleoside monophosphates as reaction products. This exonuclease activity was dependent on Mg2+ and inhibited by addition of 5 mM nucleoside monophosphates. This exonuclease activity is intrinsic to the wild-type p53 protein: it copurified with p53 during p53 preparation; only purified wild-type p53,...

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PMID: 8674115
DOI: 10.1016/s0092-8674(00)81309-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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