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Article

Proofreading exonuclease activity of human DNA polymerase delta and its effects on lesion-bypass DNA synthesis.

Nucleic acids research - 1 May 2009

Fazlieva Ruzaliya, Spittle Cynthia S, Morrissey Darlene, Hayashi Harutoshi, Yan Hong, Matsumoto Yoshihiro

Abstract excerpt

Replicative DNA polymerases possess 3' --> 5' exonuclease activity to reduce misincorporation of incorrect nucleotides by proofreading during replication. To examine if this proofreading activity modulates DNA synthesis of damaged templates, we constructed a series of recombinant human DNA polymerase delta (Pol delta) in which one or two of the three conserved Asp residues in the exonuclease domain are mutated,...

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Identifiers

PMID: 19282447
DOI: 10.1093/nar/gkp155
PMCID: PMC2685094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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