Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2010

Xu Keli, Nieuwenhuis Erica, Cohen Brenda L, Wang Wei, Canty Angelo J, Danska Jayne S, Coultas Leigh, Rossant Janet, Wu Megan Y J, Piscione Tino D, Nagy Andras, Gossler Achim, Hicks Geoff G, Hui Chi-Chung, Henkelman R Mark, Yu Lisa X, Sled John G, Gridley Thomas, Egan Sean E

Abstract excerpt

Distal lung development occurs through coordinated induction of myofibroblasts, epithelial cells, and capillaries. Lunatic Fringe (Lfng) is a beta(1-3) N-acetylglucosamine transferase that modifies Notch receptors to facilitate their activation by Delta-like (Dll1/4) ligands. Lfng is expressed in the distal lung during saccular development, and deletion of this gene impairs myofibroblast differentiation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen
Share to Elastin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosyltransferases

Share to Mice, Mutant Strains

Share to Organogenesis

Share to Pulmonary Alveoli

Share to Receptors, Notch

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 19897741
DOI: 10.1152/ajplung.90550.2008
PMCID: PMC2806195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.PMID 19897741Read ↗

Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine.Semantic proximity Read ↗

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.Semantic proximity Read ↗

Wnt5a participates in distal lung morphogenesis.Semantic proximity Read ↗

Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion.Semantic proximity Read ↗

Defects in somite formation in lunatic fringe-deficient mice.Semantic proximity Read ↗

Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.Semantic proximity Read ↗

WNT5a-ROR Signaling Is Essential for AlveologenesisSemantic proximity Read ↗

Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung.Semantic proximity Read ↗

FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasiaSemantic proximity Read ↗

Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.Semantic proximity Read ↗

Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice.Semantic proximity Read ↗

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.