Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.

Cell - 9 Apr 1993

Simon M A, Dodson G S, Rubin G M

Abstract excerpt

Activation of the sevenless protein-tyrosine kinase is required for the proper specification of R7 photoreceptors in the Drosophila eye. The activation of a Ras protein, p21Ras1, is a crucial early event in the signaling pathway, and constitutive activation of p21Ras1 is sufficient to induce all of the effects of sevenless action. Here we report that another gene, E(sev)2B, required for proper signaling by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Membrane Proteins

Share to Models, Genetic

Share to Molecular Sequence Data

Share to Protein Binding

Source

Identifiers

PMID: 8462097
DOI: 10.1016/0092-8674(93)90169-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.PMID 8462097Read ↗

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.Semantic proximity Read ↗

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.Semantic proximity Read ↗

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.Semantic proximity Read ↗

The Son of sevenless gene product: a putative activator of Ras.Semantic proximity Read ↗

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.Semantic proximity Read ↗

SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development.Semantic proximity Read ↗

A screen for genes that function downstream of Ras1 during Drosophila eye development.Semantic proximity Read ↗

Understanding SOS (Son of Sevenless).Semantic proximity Read ↗

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.Semantic proximity Read ↗

The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination.Semantic proximity Read ↗

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.Semantic proximity Read ↗

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.