Article
An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.
Cell - 9 Apr 1993
Simon M A, Dodson G S, Rubin G M
Abstract excerpt
Activation of the sevenless protein-tyrosine kinase is required for the proper specification of R7 photoreceptors in the Drosophila eye. The activation of a Ras protein, p21Ras1, is a crucial early event in the signaling pathway, and constitutive activation of p21Ras1 is sufficient to induce all...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Drosophila
- Drosophila Proteins
- Enzyme Activation
- Eye
- Eye Proteins
- Female
- In Vitro Techniques
- Male
- Membrane Glycoproteins
- Membrane Proteins
- Models, Genetic
- Molecular Sequence Data
- Photoreceptor Cells
- Protein Binding
- Protein-Tyrosine Kinases