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Article

Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119.

The Journal of biological chemistry - 28 Apr 1995

Zhong J M, Chen-Hwang M C, Hwang Y W

Abstract excerpt

We examined c-Ha-Ras harboring an aspartate to asparagine substitution at position 119 (mutation D119N). The Asp-119 is part of the conserved NKXD motif shared by members of the regulatory GTPase family. This asparagine residue has been proposed to participate in direct bonding to the guanine ring and to determine the guanine-nucleotide binding specificity. The D119N mutation was found to alter nucleotide...

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PMID: 7730301
DOI: 10.1074/jbc.270.17.10002

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SOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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