Mutational analysis of the TrkA gene in prostate cancer.

doi:10.1002/(sici)1097-0045(19980801)36:3<172::aid-pros5>3.0.co;2-j

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Article

Mutational analysis of the TrkA gene in prostate cancer.

The Prostate - 1 Aug 1998

George D J, Suzuki H, Bova G S, Isaacs J T

Abstract excerpt

BACKGROUND: TrkA, the high affinity, tyrosine kinase receptor for nerve growth factor (NGF) has been implicated as an oncogene in several neoplasms. In prostate cancer, inhibitors of the NGF/TrkA signal pathway results in tumor growth inhibition. In contrast, inhibition of this trk pathway in the...

Topics

Amino Acid Sequence
DNA Mutational Analysis
DNA Primers
Humans
Male
Molecular Sequence Data
Mutation
Nerve Growth Factors
Polymorphism, Single-Stranded Conformational
Prostatic Neoplasms
Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases
Receptor, trkA
Receptors, Nerve Growth Factor

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