Article
Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand conformation polymorphism analysis.
The Prostate - 1 Mar 1996
Evans B A, Harper M E, Daniells C E, Watts C E, Matenhelia S, Green J, Griffiths K
Abstract excerpt
It is possible that structural changes of the androgen receptor (AR) contribute to the insensitivity of prostatic carcinomas to endocrine therapy. We have isolated DNA from 58 human prostate tumor specimens (31 carcinomas pretreatment, 13 carcinomas after relapse to hormonal therapy, and 14 benig...
Topics
- Humans
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prostatic Neoplasms
- Receptors, Androgen
- Repetitive Sequences, Nucleic Acid
- Tumor Cells, Cultured