Article
Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor.
The Japanese journal of human genetics - 1 Jun 1997
Indo Y, Mardy S, Tsuruta M, Karim M A, Matsuda I
Abstract excerpt
Nerve growth factor (NGF) induces neurite outgrowth and promotes survival of embryonic sensory and sympathetic neurons. TRKA, a receptor tyrosine kinase cloned from a human colon cancer was later found to be expressed in the nervous system and phosphorylated in response to NGF. Somatic rearrangem...
Topics
- Base Sequence
- Chromosomes, Human, Pair 1
- DNA, Complementary
- Humans
- Hypohidrosis
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases
- Receptor, trkA
- Receptors, Nerve Growth Factor