Article
Mutation screening of the androgen receptor promoter and untranslated regions in prostate cancer.
The Prostate - 1 Nov 2006
Waltering Kati K, Wallén Mika J, Tammela Teuvo L J, Vessella Robert L, Visakorpi Tapio
Abstract excerpt
BACKGROUND: Mechanisms, other than gene amplification, leading to overexpression of AR in androgen ablation-resistant prostate cancer remain unknown and could include genetic alterations in the promoter or untranslated regions (UTR) of the AR gene. MATERIALS AND METHODS: DNAs from five prostate cancer cell lines, 19 LuCaP xenografts, 44 clinical tumors, and 36 non-malignant controls were used for screening...
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