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Article

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.

The EMBO journal - 3 Aug 1998

Meng F, Lowell C A

Abstract excerpt

We have used mutant macrophages which are deficient in expression of Src-family kinases to define an integrin signaling pathway that is required for macrophage adhesion and migration. Following ligation of surface integrins by fibronectin, the p120(c-cbl) (Cbl) protein rapidly becomes tyrosine phosphorylated and associated with the Src-family kinases Fgr and Lyn. In hck-/-fgr-/-lyn-/- triple mutant cells, which...

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Identifiers

PMID: 9687507
DOI: 10.1093/emboj/17.15.4391
PMCID: PMC1170772

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