Article
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.
The EMBO journal - 3 Aug 1998
Meng F, Lowell C A
Abstract excerpt
We have used mutant macrophages which are deficient in expression of Src-family kinases to define an integrin signaling pathway that is required for macrophage adhesion and migration. Following ligation of surface integrins by fibronectin, the p120(c-cbl) (Cbl) protein rapidly becomes tyrosine ph...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Adhesion
- Cell Migration Inhibition
- Cell Movement
- DNA
- Enzyme Activation
- Fibronectins
- Inflammation
- Integrin beta1
- Macrophages, Peritoneal
- Mice
- Mice, Knockout
- Mutation
- NF-kappa B
- Oligonucleotides, Antisense
- Oncogene Protein v-cbl
- Phosphatidylinositol 3-Kinases