Article
Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain.
The Journal of cell biology - 29 Apr 2002
Hirsch Emilio, Barberis Laura, Brancaccio Mara, Azzolino Ornella, Xu Dazhong, Kyriakis John M, Silengo Lorenzo, Giancotti Filippo G, Tarone Guido, Fässler Reinhard, Altruda Fiorella
Abstract excerpt
Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of beta1 integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homozygotes display defective cell cycle coupled to impaired activation of the FAK-PI3K-Akt and Rac-JNK signaling...
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