Article
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
Genes & development - 15 Feb 1994
Lowell C A, Soriano P, Varmus H E
Abstract excerpt
We have generated mice with targeted disruptions of the src-like genes hck and fgr to assess the role of these kinases in myeloid cell development and function. Hematopoiesis appears to proceed normally in both hck-l- and fgr-l- animals, and in hck-l(-)-fgr-l- double homozygotes, but phagocytosis...
Topics
- Animals
- Base Sequence
- DNA Primers
- DNA, Complementary
- Female
- Genes, src
- Genotype
- Hematopoiesis
- Homozygote
- Immunity, Innate
- Listeriosis
- Macrophages
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Molecular Sequence Data