Article
Evidence for allelic exclusion in Chinese hamster ovary cells.
The New biologist - 1 Aug 1990
Holliday R, Ho T
Abstract excerpt
Earlier results suggested that the functional hemizygosity of genes in pseudodiploid Chinese hamster ovary (CHO) cells is due to the silencing of one allele by DNA methylation. From this one could make a strong prediction that we have now been able to confirm by genetic experiments, using thymidi...
Topics
- Alleles
- Animals
- Azacitidine
- Bromodeoxyuridine
- Cell Line
- Cricetinae
- Cricetulus
- Cytarabine
- DNA
- Diploidy
- Drug Resistance
- Female
- Gene Expression
- Herpesvirus 1, Equid
- Metallothionein
- Ovary
- Thymidine Kinase
- Transformation, Genetic