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Article

Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli.

Protein expression and purification - 1 Apr 2020

Beyett Tyler S, Chen Qiuyan, Labudde Emily J, Krampen Joseph, Sharma Prateek V, Tesmer John J G

Abstract excerpt

G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors in humans and regulate numerous physiological processes through the activation of heterotrimeric G proteins. GPCR kinases (GRKs) selectively phosphorylate active GPCRs, which promotes arrestin binding, receptor internalization, and initiation of alternative signaling pathways. GRK5 is a representative member of one of three GRK...

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Identifiers

PMID: 31786308
DOI: 10.1016/j.pep.2019.105547
PMCID: PMC6994363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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