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Article

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

The EMBO journal - 16 Sept 2009

Barthet Gaël, Carrat Gaëlle, Cassier Elizabeth, Barker Breann, Gaven Florence, Pillot Marion, Framery Bérénice, Pellissier Lucie P, Augier Julie, Kang Dong Soo, Claeysen Sylvie, Reiter Eric, Banères Jean-Louis, Benovic Jeffrey L, Marin Philippe, Bockaert Joël, Dumuis Aline

Abstract excerpt

G protein-coupled receptors (GPCRs) have been found to trigger G protein-independent signalling. However, the regulation of G protein-independent pathways, especially their desensitization, is poorly characterized. Here, we show that the G protein-independent 5-HT(4) receptor (5-HT(4)R)-operated Src/ERK (extracellular signal-regulated kinase) pathway, but not the G(s) pathway, is inhibited by GPCR kinase 5...

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Identifiers

PMID: 19661922
DOI: 10.1038/emboj.2009.215
PMCID: PMC2750015

Genes

GRK5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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