Article

Analysis of molecular structure, cellular localisation and functional role of G protein-coupled receptor kinase GRK4 and related kinases

2000-01-01

Abstract excerpt

For a number of G protein-coupled receptors (GPCRs) a rapid, and reversible loss of responsiveness occurs upon exposure to agonists (homologous desensitisation). Two types of proteins play a major role in determining homologous desensitisation: G protein-coupled receptor kinases (GRK), (Chuang, 1996a; Krupnik, 1998), which phosphorylate agonist-occupied GPCRs, and the cofactor, (S)-arrestin (Krupnik 1998). The GRK...

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Literature Corpus work: d2a210e9-ccbf-52c4-bdc1-dd9215f0e3d0
DOI: 10.21954/ou.ro.0000ff8a

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