Article
Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation.
Trends in pharmacological sciences - 1 Jul 2002
Tobin Andrew B
Abstract excerpt
Although originally linked to receptor desensitization, G-protein-coupled receptor (GPCR) phosphorylation has now been implicated in coupling receptors to specific signalling pathways. Generally, this phosphorylation event is thought to be mediated by one of the members of the GPCR kinase (GRK) family. However, recent studies have indicated that protein kinases distinct from the GRK family might also be involved...
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