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Article

Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein function.

Journal of cell science - 1 Dec 2006

Eura Yuka, Ishihara Naotada, Oka Toshihiko, Mihara Katsuyoshi

Abstract excerpt

Mitofusin proteins 1 and 2 (Mfn1 and Mfn2, respectively) of the mammalian mitochondrial outer membrane are homologues of Drosophila FZO and yeast Fzo1, and both are essential for GTP-dependent mitochondrial fusion. We identified a 55-kDa Mfn-binding protein named MIB. It is a member of the medium-chain dehydrogenase/reductase protein superfamily, and has a conserved coenzyme-binding domain (CBD). The majority of...

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PMID: 17105775
DOI: 10.1242/jcs.03253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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