Article

An intermembrane space protein facilitates completion of mitochondrial division in yeast

2023-04-01

Abstract excerpt

Mitochondria are highly dynamic double membrane-bound organelles that maintain their shape in part through fission and fusion. Mitochondrial fission is performed by the dynamin-related protein Dnm1 (Drp1 in humans), a large GTPase that constricts and divides the mitochondria in a GTP hydrolysis-dependent manner. However, it is unclear whether factors inside mitochondria help coordinate the process and if Dnm1/Drp1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49f8baf0-920f-5096-9595-b2ffcec2740a
DOI: 10.1101/2023.03.31.535139

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An intermembrane space protein facilitates completion of mitochondrial division in yeastDOI 10.1101/2023.03.31.535139Read

The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission.Semantic proximity Read

Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p.Semantic proximity Read

[Mitochondrial morphology and dynamics: actors, mechanisms and functions].Semantic proximity Read

Division of mitochondria requires a novel DNM1-interacting protein, Net2p.Semantic proximity Read

The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria.Semantic proximity Read

The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagySemantic proximity Read

A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance.Semantic proximity Read

Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1.Semantic proximity Read

Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane.Semantic proximity Read

Human CCDC51 and yeast Mdm33 are functionally conserved mitochondrial inner membrane proteins that demarcate a subset of organelle fission eventsSemantic proximity Read

Mimicking human Drp1 disease-causing mutations in yeast Dnm1 reveals altered mitochondrial dynamics.Semantic proximity Read

A DRP-like pseudoenzyme coordinates with MICOS to promote cristae architectureSemantic proximity Read