Article
Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas.
Pharmacogenetics - 1 Jun 1998
Lin H J, Probst-Hensch N M, Hughes N C, Sakamoto G T, Louie A D, Kau I H, Lin B K, Lee D B, Lin J, Frankl H D, Lee E R, Hardy S, Grant D M, Haile R W
Abstract excerpt
N-acetyltransferase NAT1, together with enzymes CYP1A2 and NAT2, helps convert heterocyclic amines to mutagens. Epidemiologic studies of the association of variants of these enzymes with colorectal cancer may provide indirect support for a heterocyclic amine mechanism. We used single strand conformation polymorphism and heteroduplex analysis to screen fro mutations in the NAT1 coding region in a case-control...
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