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Article

Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.

Mutation research - 30 Sept 2002

Hein David W

Abstract excerpt

Aromatic and heterocyclic amines require metabolic activation to electrophilic intermediates that initiate carcinogenesis. N-Acetyltransferase 1 (NAT1) and 2 (NAT2) are important enzymes in the biotransformation of these carcinogens and exhibit genetic polymorphism. Human NAT1 and NAT2 alleles are listed at: http://www.louisville.edu/medschool/pharmacology/NAT.html by an international gene nomenclature committee....

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Source

Identifiers

PMID: 12351146
DOI: 10.1016/s0027-5107(02)00153-7

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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